The selected person will work in the field of nanomedicine. The contract will be within the framework of the National Project “One-pot assay for screening cancer nanomedicines: decoding bar-coded nanoparticles by DNA-PAINT microscopy (NANOCODE)”
By using DNA-PAINT microscopy, a type of super resolution microscopy which uses short oligonucleotide sequences, thousands of different types of NPs can be bar-coded and assayed all at once: a bar-code one-pot assay. The DNA-PAINT technique allows evaluating a library of different NPs, previously formulated separately, mixed in the same container at the same time. The bar-code one-pot assay provides a detection signal (which one) and localization (where) of different individual NPs according to their barcode. The project aims at obtaining precise information on the targeting, efficiency of delivery, penetration and biodistribution of NPs, with the potential of accelerating nanomedicines translation into clinic.
Deadline: 21st July 2024
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